Lung Cancer

What is lung cancer?

Lung cancer is not a single disease but rather a group of cancers that develop in the lung. Cancer occurs when cells mutate (change abnormally) and begin growing out of control. These cells form tumours that can often be seen on a chest X-ray.

Some tumours that form in the lung are benign (noncancerous), meaning they do not grow into surrounding areas or spread in the body. Malignant (cancerous) tumours grow into nearby tissues or spread to other parts of the body (metastasize). A biopsy is required to determine the diagnosis of a tumour that appears suspicious on imaging.

How does lung cancer develop?

Many patients wonder why they developed lung cancer or if they are at a high risk for the disease. In general, cancer develops after the genetic material in cells changes abnormally and the cells begin growing out of control. When there are enough of these abnormal cells, they can form a tumour.

Lung cancer often is a result of chronic exposure to tobacco smoke, either from smoking or from being around second-hand smoke. It also is linked to exposure to certain substances like radon gas or asbestos, or from prior radiation treatment to or over the lungs. People who have had lung cancer before are at higher risk of recurrence. People who have a close relative who has had lung cancer are slightly higher risk of developing the disease.

Types of Lung CancerWhat is lung cancer?

Lung cancer has 2 main types. Each type is categorized by how the cancer cells look under a microscope:

  • • Non-small cell lung cancer
    • - Squamous cell carcinoma
    • - Adenocarcinoma
    • - Bronchoalveolar carcinoma
    • - Large-cell undifferentiated carcinoma
  • • Small cell lung cancer
    • Other factors in diagnosis and treatment planning There are additional considerations beyond type and subtype that affect recommendations your care team may make for treatment.

Stages of Lung Cancer

Determination of stage of lung cancer at diagnosis is important to plan best treatment modality. Stage of the Cancer is described based on:

  • Size of the tumor
  • Location of the cancer
  • Whether the cancer has spread and, if so, to where

This information is also helpful in determining prognosis (probable outcome based on the experience of others).

The stages of lung cancer are:

  • Stage 1: Cancer is found in the lung, but not progressed to the lymph nodes or distant organs. Surgery is the best modality at this stage. However, decision is based on other factors also like fitness of the patient to undergo surgery.
  • Stage 2: Cancer has progressed from the lungs to nearby lymph nodes. Surgery followed by drug therapy is recommended.
  • Stage 3: Cancer is in the lung and has progressed to distant lymph nodes. Chemotherapy or chemoradiation may be rec
  • Stage 4 (Metastatic): Cancer has progressed beyond the lung to distant lymph nodes and other organs. This advanced stage of cancer is commonly managed by drug therapy alone.
  • Recurrent: Cancer that has come back after treatment. This may be managed by some combination of surgery, drug therapy, and radiation therapy.

Lung Cancer

Symptoms of Lung Cancer

Many early stage lung cancers can be detected by screening or incidentally as part of xrays done for other reasons. Lung cancers are often found after they produce discomfort. Signs and symptoms of lung cancer include:.

  • A chronic cough
  • Coughing up blood
  • Shortness of breath
  • Respiratory infections that won’t go away
  • Chronically hoarse voice
  • Sudden, unexplained weight loss

Risk Factors for Lung Cancer

Lung cancer risk factors include:

  • Smoking: Your risk of developing lung cancer increases with the number of cigarettes you smoke each day and the number of years you have smoked. Quitting at any age lowers your risk of developing lung cancer.
  • Exposure to radon gas: radon results from the breakdown of uranium in certain soils. The gas may make its way into homes, especially in basements.
  • Exposure to asbestos: people exposed to asbestos through their work are at greater risk of developing a condition called mesothelioma. Mesothelioma is a type of cancer that starts in the lining around the lungs.
  • Exposure to radiation: Radiation therapy to the chest from childhood through early adulthood increases lung cancer risk.
  • Family history: people with a close relative who had lung cancer are at slightly higher risk for developing lung cancer themselves.ses lung cancer risk.
  • Prior lung cancer: people who have had lung cancer before are at greater risk for recurrence of lung cancer.

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Diagnostic Tests for Lung Cancer

If the diagnosis of Lung Cancer has already been made outside, we will have your results sent to our pathologists (doctors specializing in cancer diagnosis). They will review your test results and confirm or correct your diagnosis.

At our centre, the diagnostic phase is tailored to each individual patient. If further testing is required our team will work with you to determine which tests you need. Tests may include:

Blood Tests (Blood Draws)

Several blood tests are required to help establish the diagnosis and plan the further course of treatment. Our team will carefully look at all the test that might have been done and recommend additional tests if required.

Thoracic Imaging (Radiology)

To obtain the most precise understanding of your cancer, your doctor may schedule you for different types of imaging that diagnose cancer. If you have been screened elsewhere and received abnormal results, we may perform additional imaging, if needed.

Lung Biopsy (Pathology)

If your imaging or other screening tests show that you may have cancer, you will need a biopsy. This test takes a tiny sample of cells from abnormal areas of tissue. This is done under guidenace of an imaging modality depending on the location of the tumour.

  • Ultrasound guided Lung Mass Biopsy
  • CT (Computed Tomography) Guided
  • EBUS Biopsy (Lymph Nodes or Centrally located tumours)

Test for Staging of Lung Cancer

The clinical stage or the initial staging before initiation f treatment is vitally important for patients with Lung Cancer as it is not only the basis for deciding on a patient's treatment plan, but is also the basis for comparison when checking into the patient's response to treatment. This will require

  • Whole Body PET/CT Scan
    Positron emission tomography (PET) Scan is a special imaging modality wherein a small amounts of radioactive materials called radiotracers or radiopharmaceuticals are injected in to the veins. These radiotracers accumulate in areas where there may be tumour cells and will be detected using a special camera and a computer. By identifying changes at the cellular level, PET scan may detect the early onset of disease before other imaging tests can and also help in identifying whether the disease is limited to lungs or has spread beyond it.
  • MRI Brain
    Certain patients will require MRI of the brain to rule out spread to brain which sometimes is not picked up by PET scan .
  • Endo-Bronchial Ultrasound Guided staging of Mediastinal Lymph nodes
    This test is used to check for spread of the cancer to regional or Mediastinal Nodes. It involves the use of a special bronchoscope which has an ultrasound probe at its tip. This is used to visualise the lymph nodes from which needle biopsy is taken and which is then subjected to evaluation by Pathologists for presence of cancer cells
  • Mediastinoscopy
    This is a surgical procedure which is advised in patients with Lung Cancer to conclusively rule out involvement of Mediastinal Nodes in the central part of the chets, which is the space between the heart, lungs, windpipe, and esophagus.

Lung Cancer

Treatment of Lung Cancer

Small Cell Lung Cancer

In general, small cell lung cancer patients present at a stage where the cancer has already spread beyond the lungs. Such patients are usually treated with chemotherapy. Surgery is limited to very early stage disease in patients who have not yet have lymph nodal or distant spread. It has usually spread at the time of diagnosis. So, chemotherapy is usually the main treatment. You may also have radiotherapy to treat this type of lung cancer.

Non- Small Cell Lung Cancer (NSCLC)

This cancer is treated by Surgery, Chemotherapy and Radiotherapy or in combination. If detected early Surgery appears to offer the best long-term results.

Surgical techniques to take out pulmonary nodules include:

  • Thoracotomy(Open): This procedure is considered open lung surgery. A cut is made in the wall of the chest in order to remove pieces of diseased lung tissue. Patients usually have to remain in the hospital for a few days after the operation. The mortality risk is low. When possible, a mini-thoracotomy that is less invasive may be performed
  • Video-Assisted Thoracoscopy: This procedure uses a thoracoscope, a flexible tube with a miniature camera on its end. The thoracoscope is inserted through a small cut into the chest wall. The camera allows the surgeon to view an image of the nodule on a television screen. This technique requires a smaller cut and a shorter recovery time than a thoracotomy does.

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